Enterohepatic cycle and bile salt signaling

The enterohepatic circulation (EHC) is essential for maintaining both digestive and metabolic health. Bile salts, which are produced in the liver, act as essential signaling molecules that are efficiently recycled through the EHC. This continuous cycle allows bile salts to regulate a wide range of physiological functions in both the gut and liver, including gut barrier integrity, inflammation and liver metabolism, forming a bidirectional communication network between these two organs