Understanding the Role of Bile Salt Signaling in Gut and Liver Health

Approach
Our research team is dedicated to understanding the role of bile salt signaling in maintaining the health of the intestine and liver. We also explore how disruptions in this signaling pathway contribute to various diseases. By adopting a translational approach, we work directly with surgical patients who have an impaired enterohepatic circulation, using them as a model to better understand these complex processes. In addition, we employ cutting-edge techniques, such as patient-derived organoids and tissue slices, to gain deeper insights.

Through this comprehensive approach, we aim to uncover groundbreaking findings that could lead to more effective treatments and improve patient outcomes in the future.

Analytics
A key aspect of our research involves the detailed analysis of bile salt composition in patient materials. To facilitate this, we have developed a state-of-the-art LC-MS-based quantitative assay that not only covers a comprehensive panel of standard bile salts but also includes newly discovered bile salt metabolites derived from gut microbes. This advanced analytical technique enables us to identify and quantify a wide range of bile salts and metabolites, providing valuable insights into their roles in intestinal and liver health, as well as their potential involvement in disease processes.