Unraveling Chemotherapy Resistance: Linking Tumor Metabolism, Cachexia, and Organoid InnovationAccurate Diagnosis of Cancer Cachexia with PRIMs: Advancing precision in cancer cachexia research

Traditional methods of diagnosing cachexia that rely on patient-reported weight loss data are often unreliable. We leverage new technologies to enable real-time monitoring of weight loss and daily physical activity through a Patient-Recorded Indexing Measurements (PRIMs) approach. These tools provide precise data, leading to better prognostic accuracy and more personalized treatment plans.

• Objective

The primary goal is to collect precise, longitudinal data on physical activity and body weight loss in cancer patients undergoing curative treatment (surgery or chemotherapy) and to relate these findings to treatment outcomes such as postoperative complications and chemotherapy toxicity.

• Methodology

Participants wear a wrist-worn accelerometer 24/7 and use a memory-integrated weight scale. This approach ensures continuous, accurate monitoring with minimal burden.

Comprehensive Patient Assessment at Clinical Research Unit

A baseline screening includes functional and nutritional tests such as the Timed Up and Go test, grip strength analysis, and short nutritional assessment performed by experienced physiotherapists as part of standard care.

• Key Outcomes

  - Establishing the relationship between body weight, physical activity, and adverse treatment events.

  - Linking body composition changes with survival and treatment response.

  - Providing a foundation for developing effective, personalized interventions for cancer cachexia.

By integrating advanced monitoring technologies into routine cancer care, the PRIMs study is setting new standards for cachexia research and patient management.